purR [2017-8-11 16:0:3]

transcription repressor of the pur operon

locus: BSU00470

pI: 5.77

mw: 31.08 kDa

protein length: 285 aa

gene length: 855 bp

function: regulation of purine biosynthesis

product: transcription repressor of the pur operon

essential: no

synonyms: yabI

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

Gene

Coordinates: 54,441 → 55,298

The protein

Protein family

• purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)

Effectors of protein activity

• PRPP acts as inducer, binding results in release of PurR from the operator [Pubmed|10919400]

Structure

• [PDB|1O57], 1O57 [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=25670 NCBI] [Pubmed|12837783]

Additional information

• requires [protein|285D9E676B06119F9F4D33FC62615EC844D35BC3|YabJ] for ''in vivo'' activity

Expression and Regulation

Operons

• genes: [gene|8FA635D1915108BF29A864AF4DA28ECF633F735F|ispE]-[gene|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|purR]-[gene|285D9E676B06119F9F4D33FC62615EC844D35BC3|yabJ]
  description: [Pubmed|22383849]

  regulatory mechanism

  • [protein|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|PurR]: repression, [Pubmed|7638212], in [regulon|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|PurR regulon]

  regulation

  • negative autoregulation [Pubmed|7638212]

References

Reviews

• 28031352

Original publications

• 10368157,14594850,15629952,11591660,12837783,7638212,12837784,19446032,10919400